The main goal was to develop a metabolomics approach focused at identifying suitable urinary biomarkers for early diagnosis of prostate cancer (PCa). To this purpose, gas chromatography-mass spectrometry (GC-MS) combined with multivariate statistical analysis was applied for comprehensive profiling of volatile organic compounds (VOCs) in general and, more specifically, volatile carbonyl compounds (VCCs) in urine from PCa patients.
Our findings unveiled a panel of 10 volatile biomarkers significantly altered in urine samples from PCa patients that has the potential to be used as an accurate non-invasive diagnostic tool for this malignancy.
Other institutions related to the project:
- UCIBIO/REQUIMTE, Department of Biological Sciences, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal
- Cancer Biology & Epigenetics Group, Research Center (CI-IPOP) Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal
Project supported by:
- Fundação para a Ciência e a Tecnologia (reference UID/MULTI/04546/2019)