The main goal of this project was to investigate the potential toxicity and mechanisms of action of β-keto amphetamines, which are the second most commonly used type of illicit drug worldwide after cannabis. Kidney injury has been reported in intoxications associated with these drugs, but the molecular mechanisms involved have not been explored yet. In this study, the potential in vitro nephrotoxic effects of four commonly abused cathinone derivatives were assessed in the human kidney HK-2 cell line.
The results showed that synthetic cathinones elicit in vitro toxic responses in human kidney cells. Data provided first clues to the cellular mechanisms that underlie the β-keto amphetamines-induced nephrotoxicity, which involve induction of oxidative stress, recruitment of autophagy and activation of apoptotic cell death.
Prof. Dr. Márcia Carvalho (Main Researcher)
Profª Doutora Anabela Castro
Other institutions related to the project:
- UCIBIO/REQUIMTE, Department of Biological Sciences, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal
Project supported by:
Fundação para a Ciência e a Tecnologia (reference UID/MULTI/04546/2019)